Nancie Archin is an Assistant Professor in the Infectious Diseases Division/Department of Medicine at the University of North Carolina (UNC) at Chapel Hill. She received her BS from Stony Brook University in New York and her PhD from the Department of Microbiology and Immunology at the University of Texas Health Sciences Center at San Antonio, Texas where she studied HSV-1-induced acute retinal necrosis syndrome under the supervision of her graduate advisor, Dr. Sally Atherton. She then joined the laboratory of Dr. David Margolis at UT Southwestern where she began her studies of HIV latency. Since joining the faculty at UNC, she has worked to move laboratory observations into clinical testing and applications. She has a strong and extensive publication track record on persistent HIV research, including the first study to show that HIV latency can be disrupted in vivo, studies of the reservoir in T cell subsets, studies to delineate the basic mechanisms of HIV latency, and other translational studies on using novel molecules combined with immunotherapy for latency clearance. Her laboratory's current research focus includes using molecular biology and biochemical methods to 1) define sex-specific and other factors that contribute to HIV persistence in people living with HIV with a particular focus on women, 2) define modalities to disrupt latency and clear latently infected cells, and 3) apply these observations in clinical settings.
