The Women's HIV Research Collaborative (WHRC) is a working group of the Legacy Project comprised of women who are leaders in women's health and HIV from around the United States. With community and staff members representing the NIH-funded HIV/AIDS clinical trials networks, this group provides culturally appropriate guidance and leadership in development, implementation, and dissemination of information about HIV research focused on and responsive to the needs of cisgender and transgender women and girls in the United States.

The WHRC focuses on advocating for HIV research with women living in the United States but operates with a comprehensive awareness of the potential for American women to benefit from HIV research that is being conducted internationally. To that end, WHRC's focus is domestic, but its interests are both global and optimistic.