Table of Contents
- What Is PK?
- How Is PK Studied?
- Drug Interactions and Drug Boosting
- Do Men and Women Process Drugs Differently?
- Pharmacokinetic Testing
- How to Make PK Work for You
Pharmacokinetics, also known as PK, is the study of how medications behave in and move through the body. PK is used to figure out how much drug gets into your bloodstream and how long it stays there.
Scientists study PK to determine the best dose for an HIV drug. The dose must be high enough to keep HIV from reproducing, but not so high that it causes many side effects.
The following PK values are important:
- Maximum concentration (Cmax): This is the highest level a drug reaches in the blood. When a drug is given, it reaches its peak level in the blood (Cmax) pretty quickly. The drug level then decreases as the drug is broken down and removed from the blood.
- Minimum concentration (Cmin): This is the lowest level a drug reaches in the blood. The lowest drug level, right before the next dose, is the (Cmin), or "trough" level.
- Area Under the Curve (AUC): This refers to a graph showing the drug level in the blood over time and shows total drug exposure. The total exposure to the drug with each dose is called the AUC.
- Half-life (t1/2): A drug's half-life is the amount of time required for half of the drug to be removed from the bloodstream. For example, if the dose of a drug is 100 milligrams (mg), and the half-life is eight hours, 50 mg will be left in the blood after eight hours.
- Inhibitory Quotient (IQ): The IQ of a drug shows how much drug is necessary to control the virus effectively. The IQ is different for each drug.
The PK values are used to figure out the correct dose – both the amount of drug and the timing (once a day, twice a day, etc.). In order for a drug to work, it must have a high enough minimum concentration (Cmin) and total exposure (AUC) to be effective against HIV.
PK values are also used to help avoid toxic side effects. If the maximum concentration (Cmax) gets too high, the drug can cause unwanted side effects. The goal of HIV therapy is to get the most benefit from the drug with the fewest side effects.
Last but not least, the half-life of the drug must be long enough to allow for a reasonable dose schedule. Several drugs have a long enough half-life that they only need to be taken once a day.
Liver proteins called enzymes help with drug processing. Enzymes affect drugs by breaking them down. But enzymes are also affected by drugs.
This has proven to be very useful in HIV therapy. Here is an example: Norvir (ritonavir) is a protease inhibitor (PI) that makes some enzymes work more slowly. This keeps other drugs in the body longer. So if Norvir is given with another PI, like Reyataz (atazanavir), it "boosts" Reyataz by preventing it from being broken down as quickly by the liver. Boosting with Norvir increases both the minimum concentration (Cmin) and total exposure (AUC) of Reyataz. As a result, Reyataz can be given once a day with a little Norvir. The boosted regimen makes Reyataz more effective. The majority of PIs are boosted with Norvir. There are many protease inhibitors; Reyataz is only used here as an example.
Health care providers who are aware of the pharmacokinetics of drugs and their interactions will make sure you get the right doses. That is why it is so important to let your provider know about all the medications and supplements you are taking including herbs, prescriptions, over-the-counter, and street drugs. It is okay to ask your health care provider to check to see if any of your drugs interact with each other or anything else you take.
There are some PK differences in men and women. At the same doses, some women have higher levels of certain drugs in their bloodstreams and experience more side effects than men. Despite the differences, women seem to benefit as much from HIV therapy as men.
These PK sex differences (male vs. female) may be related to hormonal changes that happen when women get their periods. PK differences also may be linked to basic biology and physiology of cells (there are differences in the cells of men and women). They may also be linked to differences in weight or body composition (amount of fat vs. lean muscle).
Standard doses of drugs are usually based on research done mostly in men. This means a woman, who generally weighs less than a man, may get a higher amount of the drug in her body than is needed to be effective. Although differences between men and women have been seen in studies, no changes to dosing of HIV drugs have been recommended for women (note: because pregnancy can change how the body processes drugs, doses of some HIV drugs may change during pregnancy).
If you are experiencing side effects, ask your health care provider for help. Do not change your dose or stop your drugs without speaking to your provider.
Other factors can also affect PK, including:
- Genetic differences in drug processing
- Tobacco and alcohol use
- Drug interactions
- Hepatitis or other liver problems
Because of PK differences, new tests are being developed to help figure out if patients are receiving the right amount of drug.
Therapeutic Drug Monitoring (TDM): TDM is designed to measure your drug levels specifically. Basically it measures minimum concentration (Cmin) by drawing blood before you take your morning meds. This measurement can also be collected through urine or hair samples. This can help your health care provider decide if the dose of your HIV drugs should be changed. TDM is expensive and is most often used in research studies. It may or may not be available through your health care provider, and is not currently recommended by the US Department of Health and Human Services for providers to use when managing regular HIV treatment in adults.
The timing of medication doses has been carefully calculated to keep the drug in your bloodstream at levels that will control HIV. When you do not take a dose on time, the level of drug in your blood becomes too low to be effective.
When this happens, HIV has a chance to make more copies of itself, which causes your viral load to go up. Having too little of an HIV drug in your blood also makes it easier for HIV to become resistant to the drug you are taking, causing it to stop working. Consequently, your viral load could go up, your CD4 cells could go down, and you might need to change drug treatments. The best way to avoid this is to take your HIV drugs exactly as they are prescribed (also called adherence). This maintains the blood level of the drugs necessary to fight the virus effectively.